RIOK3 keeps MDA5 inactive

RIOK3 keeps MDA5 inactive.

RIG-I and MDA5 are cytoplasmic RNA sensors that recognize dsRNA patterns and activate MAVS to induce innate antiviral gene program. RNA sensing is regulated by ubiquitination in RIG-I while by phosphorylation in MDA5. Thus, de novo phosphorylation is an essential step for keeping MDA5 inactive. We identified a protein kinase RIO kinase 3 (RIOK3) targeting MDA5, and here discuss its possible rel...

MDA5: the almighty for Myocardium.

MDA5-filament, dynamics and disease.

Melanoma Differentiation-Associated gene 5 (MDA5), encoded by the gene IFIH1, is a cytoplasmic sensor for viral double-stranded RNAs (dsRNAs). MDA5 activates the type I interferon signaling pathway upon detection of long viral dsRNA generated during replication of picornaviruses. Studies have shown that MDA5 forms a filament along the length of dsRNA and utilizes ATP-dependent filament dynamics...

Catenin keeps vesicles close

kinase better known for triggering DNA replication also helps create the sticky heterochromatin at centromeres of fission yeast, according to Julie Bailis, Susan Forsburg (Salk Institute, La Jolla, CA), and colleagues. The dual action makes sense, as chromosomes must be stuck together as soon as they are replicated. The responsible kinase activity, Hsk1 (CDC7)–Dfp1, is restricted to S phase, wh...

NSD3 keeps IRF3 active

Antiviral innate immune responses are a critical first line of host defense against invading viral pathogens (Akira et al., 2006; Takeuchi and Akira, 2010; Moresco et al., 2011). Viral RNA and DNA is initially recognized by pattern recognition receptors (PRRs) such as TLRs, retinoic acid– inducible gene-I (RIG-I)–like receptors (RLRs), Nod-like receptors (NLRs), and cyclic GMP-AMP (cGAMP) synth...